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Article

Resistance to levamisole resolved at the single‐channel level

1 Apr 1999

Abstract excerpt

Levamisole is commonly used to treat nematode parasite infections but therapy is limited by resistance. The purpose of this study was to determine the mechanism of resistance to this selective nicotinic drug. Levamisole receptor channel currents in muscle patches from levamisole-sensitive and levamisole-resistant isolates of the parasitic nematode Oesophagostomum dentatum were compared. The number of channels...

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PMID: 10094935
DOI: 10.1096/fasebj.13.6.749

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