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Article

Crystal structure of the oxygen-dependant coproporphyrinogen oxidase (Hem13p) of Saccharomyces cerevisiae.

The Journal of biological chemistry - 10 Sept 2004

Phillips John D, Whitby Frank G, Warby Christy A, Labbe Pierre, Yang Cheng, Pflugrath James W, Ferrara Joseph D, Robinson Howard, Kushner James P, Hill Christopher P

Abstract excerpt

Coproporphyrinogen oxidase (CPO) is an essential enzyme that catalyzes the sixth step of the heme biosynthetic pathway. Unusually for heme biosynthetic enzymes, CPO exists in two evolutionarily and mechanistically distinct families, with eukaryotes and some prokaryotes employing members of the highly conserved oxygen-dependent CPO family. Here, we report the crystal structure of the oxygen-dependent CPO from...

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Identifiers

PMID: 15194705
DOI: 10.1074/jbc.M406050200

Genes

CPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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