Article
Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases.
Nature structural biology - 1 Mar 2000
DeLaBarre B, Thompson P R, Wright G D, Berghuis A M
Abstract excerpt
The structure of the antifungal drug target homoserine dehydrogenase (HSD) was determined from Saccharomyces cerevisiae in apo and holo forms, and as a ternary complex with bound products, by X-ray diffraction. The three forms show that the enzyme is a dimer, with each monomer composed of three regions, the nucleotide-binding region, the dimerization region and the catalytic region. The dimerization and catalytic...
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