Article
No association between two MLH3 variants (S845G and P844L)and colorectal cancer risk.
Cancer genetics and cytogenetics - 1 Jul 2004
de Jong Mirjam M, Hofstra Robert M W, Kooi Krista A, Westra Jantine L, Berends Maran J W, Wu Ying, Hollema Harry, van der Sluis Tineke, van der Graaf Winette T A, de Vries Elisabeth G E, Schaapveld Michael, Sijmons Rolf H, te Meerman Gerard J, Kleibeuker Jan H
Abstract excerpt
Recently we identified a new variant, S845G, in the MLH3 gene in 7 out of 327 patients suspected of hereditary nonpolyposis colorectal cancer but not fulfilling the Amsterdam criteria and in 1 out of 188 control subjects. As this variant might play a role in causing sporadic colorectal cancer, we analyzed its prevalence in sporadic colorectal cancer patients. We analyzed a small part of exon 1 of the MLH3 gene,...
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