Article
Little evidence for involvement of MLH3 in colorectal cancer predisposition.
International journal of cancer - 20 Aug 2003
Hienonen Tuija, Laiho Päivi, Salovaara Reijo, Mecklin Jukka-Pekka, Järvinen Heikki, Sistonen Pertti, Peltomäki Päivi, Lehtonen Rainer, Nupponen Nina N, Launonen Virpi, Karhu Auli, Aaltonen Lauri A
Abstract excerpt
Mutations in the DNA MMR genes MSH2, MLH1, MSH6 and PMS2 underlie a large subset of HNPCC cases, and a hallmark of the tumors is MSI. In many HNPCC families, however, a causative mutation has not been found. Therefore, the involvement of additional, thus far unknown, genes in MSI as well as MSS colorectal tumor predisposition is possible. The role of a relatively recently cloned MMR gene, MLH3, in familial CRC...
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