Article
Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy.
Neurobiology of disease - 1 Jul 2004
Turrin Nicolas P, Rivest Serge
Abstract excerpt
In the present study, the expression of pro-inflammatory transcripts was assessed across the brain of mice having undertaken pilocarpine-induced seizures. Pilocarpine-induced marked neurodegeneration and demyelination in multiple regions of the forebrain. The pattern of genes encoding toll-like receptor type 2 (TLR2) and I kappa B alpha (index of NF-kappa B activation) was associated with the neurodegenerating...
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