Article
Genomewide screening for novel genetic variations associated with ciprofloxacin resistance in Bacillus anthracis.
Antimicrobial agents and chemotherapy - 1 Jul 2010
Serizawa Masakuni, Sekizuka Tsuyoshi, Okutani Akiko, Banno Satomi, Sata Tetsutaro, Inoue Satoshi, Kuroda Makoto
Abstract excerpt
Fluoroquinolone (FQ) resistance of Bacillus anthracis is a serious concern in the fields of biodefense and bioterrorism since FQs are very effective antibiotics and are recommended as first-line treatment against this lethal bacterium. In this study, we obtained 2 strains of B. anthracis showing resistance or intermediate resistance to ciprofloxacin (CIP) by a stepwise selection procedure with increasing CIP...
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