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Article

Inhibited gastrulation in mouse embryos overexpressing the leukemia inhibitory factor.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1992

Conquet F, Peyriéras N, Tiret L, Brûlet P

Abstract excerpt

Leukemia inhibitory factor (LIF) is a cytokine active in vitro on different target cells. It is detected in vivo during mouse gestation in both extraembryonic membranes and maternal tissues. Two isoforms have been described maintaining embryonic stem cells in culture in a pluripotent state. However, overexpression of their cDNAs in chimeric mouse embryos observed between 6.5 and 9.5 days postcoitus gave...

Topics

Animals
Base Sequence
Chimera
Cloning, Molecular
Gastrula
Growth Inhibitors
Interleukin-6
Leukemia Inhibitory Factor
Lymphokines
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1518846
DOI: 10.1073/pnas.89.17.8195
PMCID: PMC49884

Genes

LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1518846-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Inhibited gastrulation in mouse embryos overexpressing the leukemia inhibitory factor.PMID 1518846Read ↗

Role of leukemia inhibitory factor during mammalian development.Semantic proximity Read ↗

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LIF-Dependent Signaling: New Pieces in the LegoSemantic proximity Read ↗

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Requirement of FGF-4 for postimplantation mouse development.Semantic proximity Read ↗

Optimizing the Expression and Solubilization of an E. coli-Produced Leukemia Inhibitory Factor for Anti-LIF Antibody Production and Use Thereof for Contraception in Mice.Semantic proximity Read ↗

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.Semantic proximity Read ↗

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Cloning of leukemia inhibitory factor (LIF) and its expression in the uterus during embryonic diapause and implantation in the mink (Mustela vison)Semantic proximity Read ↗

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