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Article

Inhibited gastrulation in mouse embryos overexpressing the leukemia inhibitory factor.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1992

Conquet F, Peyriéras N, Tiret L, Brûlet P

Abstract excerpt

Leukemia inhibitory factor (LIF) is a cytokine active in vitro on different target cells. It is detected in vivo during mouse gestation in both extraembryonic membranes and maternal tissues. Two isoforms have been described maintaining embryonic stem cells in culture in a pluripotent state. However, overexpression of their cDNAs in chimeric mouse embryos observed between 6.5 and 9.5 days postcoitus gave...

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Identifiers

PMID: 1518846
DOI: 10.1073/pnas.89.17.8195
PMCID: PMC49884

Genes

LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Inhibited gastrulation in mouse embryos overexpressing the leukemia inhibitory factor.PMID 1518846Read ↗

Role of leukemia inhibitory factor during mammalian development.Semantic proximity Read ↗

Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice.Semantic proximity Read ↗

Effect of leukemia inhibitory factor (LIF) on in vitro produced bovine embryos and their outgrowth coloniesSemantic proximity Read ↗

LIF-Dependent Signaling: New Pieces in the LegoSemantic proximity Read ↗

Cytokine signalling in embryonic stem cellsSemantic proximity Read ↗

Requirement of FGF-4 for postimplantation mouse development.Semantic proximity Read ↗

Optimizing the Expression and Solubilization of an E. coli-Produced Leukemia Inhibitory Factor for Anti-LIF Antibody Production and Use Thereof for Contraception in Mice.Semantic proximity Read ↗

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.Semantic proximity Read ↗

Paracrine Induction of Stem Cell Renewal by LIF-Deficient Cells: A New ES Cell Regulatory PathwaySemantic proximity Read ↗

Characteristics of embryonic stem cell differentiation: a comparison with two embryonal carcinoma cell lines.Semantic proximity Read ↗

The Latent Transforming Growth Factor-β–binding Protein-1 Promotes In Vitro Differentiation of Embryonic Stem Cells into EndotheliumSemantic proximity Read ↗

Cloning of leukemia inhibitory factor (LIF) and its expression in the uterus during embryonic diapause and implantation in the mink (Mustela vison)Semantic proximity Read ↗

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