Article
Quantitative analysis of DNA methylation in chronic lymphocytic leukemia patients.
Electrophoresis - 1 Jun 2004
Lyko Frank, Stach Dirk, Brenner Axel, Stilgenbauer Stephan, Döhner Hartmut, Wirtz Michaela, Wiessler Manfred, Schmitz Oliver J
Abstract excerpt
Changes in the genomic DNA methylation level have been found to be closely associated with tumorigenesis. In order to analyze the relation of aberrant DNA methylation to clinical and biological risk factors, we have determined the cytosine methylation level of 81 patients diagnosed with chronic lymphocytic leukemia (CLL). The analysis was based on DNA hydrolysis followed by derivatization of the...
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