Article
Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Sept 2004
Hilscherova Klara, Jones Paul D, Gracia Tannia, Newsted John L, Zhang Xiaowei, Sanderson J T, Yu Richard M K, Wu Rudolf S S, Giesy John P
Abstract excerpt
The potential for a variety of environmental contaminants to disturb endocrine function in wildlife and humans has been of recent concern. While much effort is being focused on the assessment of effects mediated through steroid hormone receptor-based mechanisms, there are potentially several other mechanisms that could lead to endocrine disruption. Recent studies have demonstrated that a variety of xenobiotics...
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