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Article

Atrazine-induced aromatase expression is SF-1 dependent: implications for endocrine disruption in wildlife and reproductive cancers in humans.

Environmental health perspectives - 1 May 2007

Fan WuQiang, Yanase Toshihiko, Morinaga Hidetaka, Gondo Shigeki, Okabe Taijiro, Nomura Masatoshi, Komatsu Tomoko, Morohashi Ken-Ichirou, Hayes Tyrone B, Takayanagi Ryoichi, Nawata Hajime

Abstract excerpt

BACKGROUND: Atrazine is a potent endocrine disruptor that increases aromatase expression in some human cancer cell lines. The mechanism involves the inhibition of phosphodiesterase and subsequent elevation of cAMP. METHODS: We compared steroidogenic factor 1 (SF-1) expression in atrazine responsi...

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Identifiers

PMID: 17520059
DOI: 10.1289/ehp.9758
PMCID: PMC1867956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17520059-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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