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Article

Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation.

Molecular microbiology - 1 Jun 2004

Olano Carlos, Moss Steven J, Braña Alfredo F, Sheridan Rose M, Math Vidya, Weston Alison J, Méndez Carmen, Leadlay Peter F, Wilkinson Barrie, Salas José A

Abstract excerpt

The 18-membered polyketide macrolide borrelidin exhibits a number of important biological activities, including potent angiogenesis inhibition. This has prompted two recent total syntheses as well as the cloning of the biosynthetic gene cluster from Streptomyces parvulus Tü4055. Borrelidin possesses some unusual structural characteristics, including a cyclopentane carboxylic acid moiety at C17 and a nitrile...

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PMID: 15186422
DOI: 10.1111/j.1365-2958.2004.04090.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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