Article
NBS1 657del5 mutation may contribute only to a limited fraction of breast cancer cases in Russia.
International journal of cancer - 20 Apr 2005
Buslov Konstantin G, Iyevleva Aglaya G, Chekmariova Elena V, Suspitsin Evgeny N, Togo Alexandr V, Kuligina Ekatherina Sh, Sokolenko Anna P, Matsko Dmitry E, Turkevich Elena A, Lazareva Yulia R, Chagunava Oleg L, Bit-Sava Elena M, Semiglazov Vladimir F, Devilee Peter, Cornelisse Cees, Hanson Kaido P, Imyanitov Evgeny N
Abstract excerpt
The gene for Nijmegen chromosomal breakage syndrome (NBS1) plays a role in a variety of processes protecting chromosomal stability. Recently, it was suggested in a Polish case-control study that the founder hypomorphic mutation in NBS1, 657del5, which occurs in approximately 0.5% of Slavic subjects, may be associated with an increased risk of breast cancer (BC). We attempted to validate these findings in Russian...
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