Article
Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage.
Human genetics - 1 Aug 2004
Xu Jianfeng, Langefeld Carl D, Zheng S Lilly, Gillanders Elizabeth M, Chang Bao-Li, Isaacs Sarah D, Williams Adrienne H, Wiley Kathy E, Dimitrov Latchezar, Meyers Deborah A, Walsh Patrick C, Trent Jeffrey M, Isaacs William B
Abstract excerpt
The tumor suppressor functions of PTEN and CDKN1B have been extensively characterized. Recent data from mouse models suggest that, for some organs, the combined action of both PTEN and CDKN1B has a stronger tumor suppressor function than each alone; for the prostate, heterozygous knockout of both genes leads to 100% penetrance for prostate cancer. To assess whether such an interaction contributes to an increased...
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