Article
Influence of the amyloid precursor protein locus on dementia in Down syndrome.
Neurology - 8 Jun 2004
Margallo-Lana M, Morris C M, Gibson A M, Tan A L, Kay D W K, Tyrer S P, Moore B P, Ballard C G
Abstract excerpt
BACKGROUND: The amyloid precursor protein (APP) locus on chromosome 21 influences the development of Alzheimer disease. METHOD: The authors investigated the relationship between a tetranucleotide repeat on intron 7 of the APP gene and the age at onset of dementia in Down syndrome (DS). RESULTS: There was a 13-year difference in the age at onset of dementia in DS associated with the number of tetranucleotide...
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