Article
Genotypic variation and stability of four variable-number tandem repeats and their suitability for discriminating strains of Mycobacterium leprae.
Journal of clinical microbiology - 1 Jun 2004
Truman Richard, Fontes Amanda B, De Miranda Antonio B, Suffys Philip, Gillis Thomas
Abstract excerpt
It has not been possible to distinguish different strains of Mycobacterium leprae according to their genetic sequence. However, the genome contains several variable-number tandem repeats (VNTR), which have been used effectively in strain typing of other bacteria. To determine their suitability for differentiating M. leprae, we developed PCR systems to amplify 5 different VNTR loci and examined a battery of 12 M....
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