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Article

Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel.

The Journal of biological chemistry - 27 Aug 2004

Meredith Andrea L, Thorneloe Kevin S, Werner Matthias E, Nelson Mark T, Aldrich Richard W

Abstract excerpt

BK large conductance voltage- and calcium-activated potassium channels respond to elevations in intracellular calcium and membrane potential depolarization, braking excitability of smooth muscle. BK channels are thought to have a particularly prominent role in urinary bladder smooth muscle function and therefore are candidate targets for overactive bladder therapy. To address the role of the BK channel in urinary...

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Identifiers

PMID: 15184377
DOI: 10.1074/jbc.M405621200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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