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Article

The P4-phospholipid flippase Atp11a is required for maintenance of eye and ear structure in zebrafish.

Journal of cell science - 15 May 2025

Hawkey-Noble Alexia, Tobin Cameron, Ameen Muhammad T, Osmond Liam, Gill Colby, Bottaro Christina S, Young Terry-Lynn, French Curtis R

Abstract excerpt

The atp11a gene encodes a phospholipid flippase protein required to flip phosphatidylserine (PS) and phosphatidylethanolamine (PE) from the outer leaflet of the cytoplasmic membrane to the inner leaflet. Mutations in ATP11A have been described in individuals with sensorineural hearing loss and neurological deterioration; however, little is known regarding the mechanism by which loss of atp11a results in such...

Read the complete abstract on PubMed

Topics

Animals
Zebrafish
Zebrafish Proteins
Phospholipid Transfer Proteins
Eye
Larva

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Mitochondria

Source

Open in PubMed Open full text

Identifiers

PMID: 40223426
DOI: 10.1242/jcs.263657
PMCID: PMC12148042

Genes

ATP11A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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