Article
Notes on the maximum likelihood estimation of haplotype frequencies.
Annals of human genetics - 1 May 2004
Mano S, Yasuda N, Katoh T, Tounai K, Inoko H, Imanishi T, Tamiya G, Gojobori T
Abstract excerpt
The maximum likelihood estimation (MLE) is one of the most popular ways to estimate haplotype frequencies of a population with genotype data whose linkage phases are unknown. The MLE is commonly implemented in the use of the Expectation-Maximization (EM) algorithm. It is known that the EM algorithm carries the risk that an estimator may converge erroneously to one of the local maxima or saddle points of the...
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