Article
Cholesterol-lowering independent regression and stabilization of atherosclerotic lesions by pravastatin and by antimonocyte chemoattractant protein-1 therapy in nonhuman primates.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2004
Kitamoto Shiro, Nakano Kaku, Hirouchi Yasuhiko, Kohjimoto Yoshiro, Kitajima Shunichi, Usui Makoto, Inoue Shujiro, Egashira Kensuke
Abstract excerpt
OBJECTIVE: Anti-atherosclerotic effects of statins might be mediated partly by pleiotropic cholesterol-lowering independent mechanisms. We used nonhuman primates and examined whether treatment with pravastatin or antimonocyte chemoattractant protein-1 (MCP-1) therapy can induce regression and stabilization of established atherosclerotic lesions through cholesterol-lowering independent mechanisms. METHODS AND...
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