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Article

Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.

Developmental cell - 1 Jun 2004

Koziel Lydia, Kunath Melanie, Kelly Olivia G, Vortkamp Andrea

Abstract excerpt

Exostosin1 (Ext1) belongs to a family of glycosyltransferases necessary for the synthesis of the heparan sulfate (HS) chains of proteoglycans, which regulate signaling of several growth factors. Loss of tout velu (ttv), the homolog of Ext1 in Drosophila, inhibits Hedgehog movement. In contrast, we show that reduced HS synthesis in mice carrying a hypomorphic mutation in Ext1 results in an elevated range of Indian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15177029
DOI: 10.1016/j.devcel.2004.05.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.PMID 15177029Read ↗

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The pathogenic roles of heparan sulfate deficiency in hereditary multiple exostoses.Semantic proximity Read ↗

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Heparan sulfate in skeletal development, growth, and pathology: The case of hereditary multiple exostosesSemantic proximity Read ↗

Abrogation of heparan sulfate synthesis in<i>Drosophila</i>disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathwaysSemantic proximity Read ↗

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A novel mutation in ext2 caused hereditary multiple exostoses through reducing the synthesis of heparan sulfateSemantic proximity Read ↗

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