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Abrogation of heparan sulfate synthesis in<i>Drosophila</i>disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways

6 Apr 2004

Abstract excerpt

Studies in Drosophila and vertebrate systems have demonstrated that heparan sulfate proteoglycans (HSPGs) play crucial roles in modulating growth factor signaling. We have isolated mutations in sister of tout velu (sotv), a gene that encodes a co-polymerase that synthesizes HSPG glycosaminoglycan (GAG) chains. Our phenotypic and biochemical analyses reveal that HS levels are dramatically reduced in the absence of...

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PMID: 15056609
DOI: 10.1242/dev.01061

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