Article
Reprint of: Heparan sulfate as a regulator of endochondral ossification and osteochondroma development
1 Apr 2014
Abstract excerpt
Most elements of the vertebrate skeleton are formed by endochondral ossification. This process is initiated with mesenchymal cells that condense and differentiate into chondrocytes. These undergo several steps of differentiation from proliferating into hypertrophic chondrocytes, which are subsequently replaced by bone. Chondrocyte proliferation and differentiation are tightly controlled by a complex network of...
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