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Article

Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.

Development (Cambridge, England) - 1 Apr 2004

Han Chun, Belenkaya Tatyana Y, Khodoun Marat, Tauchi Miyuki, Lin Xinda, Lin Xinhua

Abstract excerpt

Heparan sulfate proteoglycans (HSPG) have been implicated in regulating the signalling activities of secreted morphogen molecules including Wingless (Wg), Hedgehog (Hh) and Decapentaplegic (Dpp). HSPG consists of a protein core to which heparan sulfate (HS) glycosaminoglycan (GAG) chains are attached. The formation of HS GAG chains is catalyzed by glycosyltransferases encoded by members of the EXT family of...

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Source

Identifiers

PMID: 14998928
DOI: 10.1242/dev.01051

Genes

EXT1
EXT2
EXTL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.PMID 14998928Read ↗

Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans.Semantic proximity Read ↗

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Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification.Semantic proximity Read ↗

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion.Semantic proximity Read ↗

Abrogation of heparan sulfate synthesis in<i>Drosophila</i>disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathwaysSemantic proximity Read ↗

A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses.Semantic proximity Read ↗

Distinct tissue-specificity of three zebrafish ext1 genes encoding proteoglycan modifying enzymes and their relationship to somitic Sonic hedgehog signaling.Semantic proximity Read ↗

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate.Semantic proximity Read ↗

EXT genes are differentially expressed in bone and cartilage during mouse embryogenesisSemantic proximity Read ↗

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.Semantic proximity Read ↗

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