Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion.

doi:10.1038/27932

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Article

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion.

Nature - 2 Jul 1998

Bellaiche Y, The I, Perrimon N

Abstract excerpt

Hedgehog (Hh) proteins act through both short-range and long-range signalling to pattern tissues during invertebrate and vertebrate development. The mechanisms allowing Hedgehog to diffuse over a long distance and to exert its long-range effects are not understood. Here we identify a new Drosophi...

Topics

Amino Acid Sequence
Animals
Body Patterning
Cloning, Molecular
Drosophila
Drosophila Proteins
Genes, Insect
Genes, Tumor Suppressor
Hedgehog Proteins
Humans
Insect Proteins
Membrane Proteins
Molecular Sequence Data
Mutation
N-Acetylglucosaminyltransferases
Proteins
Signal Transduction
Exostosin 2

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Open in PubMed

Identifiers

PMID: 9665133
DOI: 10.1038/27932

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9665133-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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