A conditional secretory mutant in an Ig L chain is caused by replacement of tyrosine/phenylalanine 87 with histidine.

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Article

A conditional secretory mutant in an Ig L chain is caused by replacement of tyrosine/phenylalanine 87 with histidine.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1992

Dul J L, Burrone O R, Argon Y

Abstract excerpt

The kappa-chain of the myeloma MOPC 21 is an unusual L chain, in that it is not secreted unless complexed with a H chain. This nonsecreted kappa-chain seems to be retained in the endoplasmic reticulum in association with the protein BiP/GRP78, both in myeloma cells and when expressed in COS-1 fib...

Topics

Base Sequence
Histidine
Immunoglobulin kappa-Chains
In Vitro Techniques
Macromolecular Substances
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Phenylalanine
Protein Binding
Protein Conformation
Structure-Activity Relationship
Tumor Cells, Cultured
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 1517562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1517562-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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