Article
Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV.
The Journal of biological chemistry - 13 Aug 2004
Bjelke Jais R, Christensen Jesper, Branner Sven, Wagtmann Nicolai, Olsen Christina, Kanstrup Anders B, Rasmussen Hanne B
Abstract excerpt
Human dipeptidyl peptidase IV (DPP-IV) is a ubiquitously expressed type II transmembrane serine protease. It cleaves the penultimate positioned prolyl bonds at the N terminus of physiologically important peptides such as the incretin hormones glucagon-like peptide 1 and glucose-dependent insulinotropic peptide. In this study, we have characterized different active site mutants. The Y547F mutant as well as the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.