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Article

Role of Asp102 in the catalytic relay system of serine proteases: a theoretical study.

Journal of the American Chemical Society - 9 Jun 2004

Ishida Toyokazu, Kato Shigeki

Abstract excerpt

The role of Asp102 in the catalytic relay system of serine proteases is studied theoretically by calculating the free energy profiles of the single proton-transfer reaction by the Asn102 mutant trypsin and the concerted double proton-transfer reaction (so-called the charge-relay mechanism) of the wild-type trypsin. For each reaction, the reaction free energy profile of the rate-determining step (the tetrahedral...

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Identifiers

PMID: 15174882
DOI: 10.1021/ja030405u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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