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Article

Antitumor effect of intratumoral administration of bone marrow-derived dendritic cells transduced with wild-type p53 gene.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2004

Murakami Takayoshi, Tokunaga Naoyuki, Waku Toshihiko, Gomi Shinya, Kagawa Shunsuke, Tanaka Noriaki, Fujiwara Toshiyoshi

Abstract excerpt

PURPOSE: Dendritic cells (DCs) are attractive effectors for cancer immunotherapy because of their potential to function as professional antigen-presenting cells for initiating cellular immune responses. The tumor suppressor gene p53 is pivotal in the regulation of apoptosis, and approximately 50% of human malignancies exhibit mutation and aberrant expression of p53. We investigated the antitumor effect of...

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PMID: 15173096
DOI: 10.1158/1078-0432.CCR-03-0599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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