Article
Antitumor effect of intratumoral administration of dendritic cell combination with vincristine chemotherapy in a murine fibrosarcoma model.
Histology and histopathology - 1 Apr 2003
Shin J Y, Lee S K, Kang C D, Chung J S, Lee E Y, Seo S Y, Lee S Y, Baek S Y, Kim B S, Kim J B, Yoon S
Abstract excerpt
A new antitumor therapeutic strategy utilizing the combined effect of chemotherapy and DC (dendritic cell)-based immunotherapy was designed, and the effect of intratumoral injections of unpulsed, immature DCs was evaluated after in vivo pretreatment of vincristine on tumor growth in a murine fibrosarcoma tumor model. Vincristine exerted a much more potent apoptosis/necrosis-inducing effect on MCA-102 tumor cells...
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