Article
No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found.
Neuroscience letters - 10 Jun 2004
Johnson Janel, Ostojic Jovanka, Lannfelt Lars, Glaser Anna, Basun Hans, Rogaeva Ekaterina, Kawarai Toshitaka, Bruni Amalia, St George Hyslop Peter H, Goate Alison, Pastor Pau, Chakraverty Sumi, Norton Joanne, Morris John C, Hardy John, Singleton Andrew
Abstract excerpt
Given the remarkable similarities between the genetics of tau diseases and the genetics of alpha-synuclein diseases, and given the fact that we have recently found a triplication of the alpha-synuclein locus in a family in which we had shown linkage to the alpha-synuclein locus, we determined to test whether some of the several families with autosomal dominant frontal temporal dementia which show genetic linkage...
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