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Article

Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications.

Annals of neurology - 1 Feb 2004

Farrer Matt, Kachergus Jennifer, Forno Lysia, Lincoln Sarah, Wang Deng-Shun, Hulihan Mary, Maraganore Demetrius, Gwinn-Hardy Katrina, Wszolek Zbigniew, Dickson Dennis, Langston J William

Abstract excerpt

Genomic triplication of the alpha-synuclein gene recently has been associated with familial Parkinson's disease in the Spellman-Muenter kindred. Here, we present an independent family, of Swedish-American descent, with hereditary early-onset parkinsonism with dementia due to alpha-synuclein triplication. Brain tissue available from affected individuals in both kindreds provided the opportunity to compare their...

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PMID: 14755720
DOI: 10.1002/ana.10846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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