Article
Progressive supranuclear gaze palsy is in linkage disequilibrium with the tau and not the alpha-synuclein gene.
Neurology - 1 Jan 1998
Higgins J J, Litvan I, Pho L T, Li W, Nee L E
Abstract excerpt
We studied two candidate genes, tau (tau) and alpha-synuclein (SNCA), for evidence of linkage disequilibrium on a group of unrelated individuals with progressive supranuclear palsy (PSP) and a group of age-matched control subjects. The tau alpha1 allele and the tau alpha1alpha1 genotype were overrepresented in individuals with PSP and the tau polymorphism was in linkage disequilibrium with the PSP disease locus...
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