Article
The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries.
Nature genetics - 1 Jul 1998
Kusumi K, Sun E S, Kerrebrock A W, Bronson R T, Chi D C, Bulotsky M S, Spencer J B, Birren B W, Frankel W N, Lander E S
Abstract excerpt
Pudgy (pu) homozygous mice exhibit clear patterning defects at the earliest stages of somitogenesis, resulting in adult mice with severe vertebral and rib deformities. By positional cloning and complementation, we have determined that the pu phenotype is caused by a mutation in the delta-like 3 g...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- DNA, Complementary
- Glycosyltransferases
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
- Mice
- Molecular Sequence Data
- Mutation
- Proteins
- Somites