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Article

The expression of functional human parathyroid hormone in a gene therapy model for osteoporosis.

Cell and tissue research - 1 Jul 2004

Liu Bainan, Tang Jianguo, Ji Jianguo, Gu Jun

Abstract excerpt

The pro-peptide sequence of human parathyroid hormone (hPTH) is essential for the efficient translocation of the nascent polypeptide and the precise cleavage at residue +1 from the cleavage site. If residue +1 is not a serine, the bioactivity of hPTH decreases dramatically. In order to express the functional hPTH properly in a gene therapy model, we constructed three sets of eukaryotic expression vectors: one...

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Source

Identifiers

PMID: 15170564
DOI: 10.1007/s00441-004-0903-9

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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