Article
[Design and activity verification of human parathyroid hormone (1-34) mutant protein].
Yao xue xue bao = Acta pharmaceutica Sinica - 1 Jul 2012
Qiu Shuang, Jiang Yue-Shui, Li Zhi-Qin, Lei Jian-Yong, Chen Yun, Jin Jian
Abstract excerpt
Through protein-protein BLAST of homologous sequences in different species in NCBI database and preliminary simulating molecular docking and molecular dynamics by computer software discovery studio 3.1, three amino acids R25K26K27 of natural human parathyroid hormone (1-34) with Q25E26L27 were mutated and the biological activity of the mutant peptide was evaluated. Result showed that: root mean superposition...
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