Article
[Regulation of parathyroid hormone in molecular biological aspect].
Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1995
Tokumaru H, Seino Y
Abstract excerpt
The synthesis of human parathyroid hormon (PTH) is controlled by extracellular Ca2+ concentration and 1,25 (OH)2D3, independently, nCaRE (negative calcium responsive element) and nVDRE (negative vitamin D responsive element) have been detected on 5' flanking region of human PTH gene. And also gene mutations of PTH in hereditary hypoparathyroidism was discovered in hereditary hypoparathyroidism.
Topics
- Animals
- Base Sequence
- Calcitriol
- Calcium
- Humans
- Hypoparathyroidism
- Molecular Sequence Data
- Mutation
- Parathyroid Glands
- Parathyroid Hormone
- Transcription, Genetic