The heritability of breast cancer: a Bayesian correlated frailty model applied to Swedish twins data.

doi:10.1375/136905204323016168

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Article

The heritability of breast cancer: a Bayesian correlated frailty model applied to Swedish twins data.

Twin research : the official journal of the International Society for Twin Studies - 1 Apr 2004

Locatelli Isabella, Lichtenstein Paul, Yashin Anatoli I

Abstract excerpt

The aim of this study was to investigate the role of genes and environment in susceptibility to breast cancer and to give an estimate of heritability in the propensity to develop the disease. To do this we applied an interdisciplinary approach, merging models developed in the field of demography and survival analysis - so-called frailty models - and models coming from quantitative genetics and epidemiology,...

Topics

Bayes Theorem
Breast Neoplasms
Demography
Disease Susceptibility
Diseases in Twins
Environment
Female
Genetic Predisposition to Disease
Humans
Models, Biological
Models, Genetic
Registries
Survival Analysis
Sweden

Source

Open in PubMed

Identifiers

PMID: 15169603
DOI: 10.1375/136905204323016168

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