Article
A full genome scan for age-related maculopathy.
Human molecular genetics - 22 May 2000
Weeks D E, Conley Y P, Mah T S, Paul T O, Morse L, Ngo-Chang J, Dailey J P, Ferrell R E, Gorin M B
Abstract excerpt
Age-related macular degeneration or age-related maculopathy (ARM) is a major public health issue, as it is the leading cause of irreversible vision loss in the elderly in the Western world. Using three diagnostic models, we have genotyped markers in 16 plausible candidate regions and have carried out a genome-wide screen for ARM susceptibility loci. A panel of 225 ARM families comprising up to 212 affected sib...
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