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Article

Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration.

American journal of human genetics - 1 Jan 2004

Iyengar Sudha K, Song Danhong, Klein Barbara E K, Klein Ronald, Schick James H, Humphrey Jennifer, Millard Christopher, Liptak Rachel, Russo Karlie, Jun Gyungah, Lee Kristine E, Fijal Bonnie, Elston Robert C

Abstract excerpt

To examine the genetic basis of age-related macular degeneration (ARMD), a degenerative disease of the retinal pigment epithelium and neurosensory retina, we conducted a genomewide scan in 34 extended families (297 individuals, 349 sib pairs) ascertained through index cases with neovascular disease or geographic atrophy. Family and medical history was obtained from index cases and family members. Fundus...

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Identifiers

PMID: 14691731
DOI: 10.1086/380912
PMCID: PMC1181910

Genes

EFEMP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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