Article

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

2022-07-29

Abstract excerpt

αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines and human xenograft models have reported tumor suppressor or tumor promoter (oncogene) roles for αB-Crystallin depending on cellular context and environmental conditions. To determine the causal relationship...

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Literature Corpus work: be8f008b-0ada-50d3-903a-29ba1ba989e5
DOI: 10.1101/2022.07.27.501790

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