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Article

The distribution of fitness effects caused by single-nucleotide substitutions in an RNA virus.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2004

Sanjuán Rafael, Moya Andrés, Elena Santiago F

Abstract excerpt

Little is known about the mutational fitness effects associated with single-nucleotide substitutions on RNA viral genomes. Here, we used site-directed mutagenesis to create 91 single mutant clones of vesicular stomatitis virus derived from a common ancestral cDNA and performed competition experiments to measure the relative fitness of each mutant. The distribution of nonlethal deleterious effects was highly...

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Identifiers

PMID: 15159545
DOI: 10.1073/pnas.0400146101
PMCID: PMC420405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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