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Article

Genetic switchboard for synthetic biology applications.

Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2012

Callura Jarred M, Cantor Charles R, Collins James J

Abstract excerpt

A key next step in synthetic biology is to combine simple circuits into higher-order systems. In this work, we expanded our synthetic riboregulation platform into a genetic switchboard that independently controls the expression of multiple genes in parallel. First, we designed and characterized riboregulator variants to complete the foundation of the genetic switchboard; then we constructed the switchboard...

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PMID: 22454498
DOI: 10.1073/pnas.1203808109
PMCID: PMC3326468

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