Article
Culture of large vessel endothelial cells on floating collagen gels promotes a phenotype characteristic of endothelium in vivo.
Differentiation; research in biological diversity - 1 Apr 2004
Beck Laurence H, Goodwin Anne M, D'Amore Patricia A
Abstract excerpt
The vascular endothelium in vivo is a remarkably quiescent cell layer that displays a highly differentiated and tissue-specific phenotype. Once established in culture, endothelial cells (EC) are phenotypically different from their in situ counterparts, displaying altered gene expression, increased mitotic index, and decreased cell density. To determine whether manipulating the microenvironment of cells in vitro...
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