Article
Progressive modulation of endothelial phenotype during in vitro blood vessel formation.
Developmental biology - 1 Aug 1991
Howard P S, Myers J C, Gorfien S F, Macarak E J
Abstract excerpt
"Sprouting" vascular endothelial cells were used as an in vitro model system to study the progressive morphologic and biosynthetic changes associated with the formation of tubular structures. In vitro, sprouting endothelial cells formed spontaneously without the addition of any exogenous factors from cultures of cloned endothelium exhibiting a polygonal/cobblestone phenotype. These phenotypically variant...
Topics
- Animals
- Cattle
- Cells, Cultured
- Collagen
- Endothelium, Vascular
- Extracellular Matrix Proteins
- Female
- Fibronectins
- Fluorescent Antibody Technique
- Heart Ventricles
- Neovascularization, Pathologic