Article
Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus.
Antimicrobial agents and chemotherapy - 1 Jun 2004
Ender Miriam, McCallum Nadine, Adhikari Rajan, Berger-Bächi Brigitte
Abstract excerpt
Transformation of a type I SCCmec element into Staphylococcus aureus yielded highly oxacillin-resistant transformants with a reduced growth rate. Faster-growing variants could again be selected at the cost of reduced resistance levels, demonstrating an inverse correlation between oxacillin resistance levels and growth rate.
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