Article
Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids.
Science (New York, N.Y.) - 7 Feb 2003
Deres Karl, Schröder Claus H, Paessens Arnold, Goldmann Siegfried, Hacker Hans Jörg, Weber Olaf, Krämer Thomas, Niewöhner Ulrich, Pleiss Ulrich, Stoltefuss Jürgen, Graef Erwin, Koletzki Diana, Masantschek Ralf N A, Reimann Anja, Jaeger Rainer, Gross Rainer, Beckermann Bernhard, Schlemmer Karl-Heinz, Haebich Dieter, Rübsamen-Waigmann Helga
Abstract excerpt
Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-alpha and the nucleosidic inhibitors of the viral polymerase, 3TC and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon and the substantial resistance of the virus to nucleosidic inhibitors. Potent new antiviral compounds suitable for monotherapy or combination...
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