Article
Renin-angiotensin system gene polymorphisms: its impact on IgAN and its progression to end-stage renal failure among Chinese in Singapore.
Nephron. Physiology - 1 Jan 2004
Lau Yeow-Kok, Woo Keng-Thye, Choong Hui-Lin, Zhao Yi, Tan Hui-Boon, Chong Stephanie Mun-Chung Fook, Tan Eng-King, Yap Hui-Kim, Wong Kok-Seng
Abstract excerpt
BACKGROUND: Gene polymorphisms in angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin II type 1 receptor (ATR) had been associated with IgA nephropathy (IgAN) and its progression. Several studies on Caucasian and Japanese had reported contradicting results. We determined these polymorphisms in 118 Chinese patients with IgAN and 94 healthy Chinese to assess their clinical impact. METHODS:...
Topics
- Adult
- Angiotensinogen
- China
- Disease Progression
- Female
- Genetic Predisposition to Disease
- Glomerulonephritis, IGA
- Humans
- Kidney Failure, Chronic
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
- Polymorphism, Genetic