Article
Disorder-associated mutations lead to functional inactivation of neuroligins.
Human molecular genetics - 15 Jul 2004
Chih Ben, Afridi Shehla Khan, Clark Lorraine, Scheiffele Peter
Abstract excerpt
Autism is a neuro-developmental syndrome that affects 0.1-0.5% of the population. It has been proposed that alterations in neuronal circuitry and/or neuronal signaling are responsible for the behavioral and cognitive aberrations in autism patients. However, the cellular basis of such alterations is unknown. Recently, point mutations in a family of neuronal cell adhesion molecules called neuroligins have been...
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