Article
Not all neuroligin 3 and 4X missense variants lead to significant functional inactivation.
Brain and behavior - 1 Sept 2017
Xu Xiaojuan, Hu Zhengmao, Zhang Lusi, Liu Hongfang, Cheng Yuemei, Xia Kun, Zhang Xuehong
Abstract excerpt
INTRODUCTION: Neuroligins are postsynaptic cell adhesion molecules that interact with neurexins to regulate the fine balance between excitation and inhibition of synapses. Recently, accumulating evidence, involving mutation analysis, cellular assays, and mouse models, has suggested that neuroligin (NLGN) mutations affect synapse maturation and function. Previously, four missense variations [p.G426S (NLGN3),...
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